Play and experience the exciting world of GTA 5 with a free & fully working GTA 5 Keygen that generates unique keys that can be used to redeem the game either. Download Grand Theft Auto IV, GTA 4 Full Game Free for PCCategories: PC | 5. Download Grand Theft Auto IV, GTA 4 Full Game Free for PC. ![]() ![]() Today you have the opportunity to download the patch 1.0.1180.2 for GTA Online, which contains various fixes and updates "Smuggler's Run". Unlike previous. Rockstar Games is back with the fourth game in Grand Theft Auto series, Grand Theft Auto IV. This is a action adventure game with a open gameplay with an entire city at your disposal. The game is set in Liberty City, which may be assumed to be a replica of New York. The game’s main character, Niko Bellic is from an eastern European country, he came to United States to live his life peacefully. But fate is not on his side and he gets mixed with the wrong crowd. Keep reading to Download Grand Theft Auto IV, GTA 4 Full Game Free for PC. As with all GTA games you have free reign for what you want to do. You can drive around the city, race your cars or shoot people in a third person game. ![]() You also have a multitude of online options to play with. This was one of the most anticipated games of the year. And it proved to be one of the best with many game review sites awarding it with best game awards. GTA 4 like its predecessors gives an open world for you to wander around. You can travel on foot or you can hijack a car and drive around. You can swim sprint use weapons as you like. Boats, helicopters, motorcycles and a long list of cars are all drivable by the player. Open world game gives the player the option of playing as he likes, but you need to complete missions given to you to progress through the game. You can also take on side missions like destroying hardcore criminals from the city or take part in races on the streets. You have 2 different ending to the game. Which ending you will get to depends on the choices you make in course of the game. You will either make a deal at the end with Dimitri or you can kill him to take revenge. Both decisions will have their consequences with one of the two people who are helping Niko getting killed. Download Grand Theft Auto IV, GTA 4 Full Game Free for PC from the link at the bottom. GTA 4 improves the combat system with use of cover system. You have more moves for hand to hand combat. You can also perform stylish executions in some parts of the story. Your health and armour are indicated on the screen. If you have a target selected you will see his health and armour indicators also. Health can be recovered using many options that are presented to you like, eating, sleeping, drinking and calling the hospital. If you reach zero health you will taken to a hospital and revived but will lose some money for it. 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So to Download Grand Theft Auto IV, GTA 4 Full Game Free for PC, go to the following link. Incoming search terms: gta 4 pc download free full gamedownload GTA 4gta 4 free downloadgta 4 download. Grand Theft Auto IV Download. DIABLO 2 PC Games Download Free Full Version Windows. DIABLO 2 Quick Setup (1. Working Link)Diablo II is developed underneath the banner of Blizzard North for Microsoft Windows. It had been launched on 3. June 2. 00. 0 and Blizzard Leisure printed this match. It is actually the sequel to your famed activity Diablo. You are able to also download Risen 3 Titan Lord. Diablo II match is plotted once the functions on the first recreation has transpired. The warrior who has defeated Diablo is becoming corrupted because of the demonic spirits. He’s now the reason for entrance of demons on the earth and they are triggering havoc. Inside the current day a bunch of explorers pass through Rogue Encampment. 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It was Volvo’s semi- autonomous driving technology at work, and it scared me to death. It wasn’t supposed to be like this. The Volvo V9. 0 station wagon that the company let me test for a week is supposed to be one of the safest and most sophisticated cars you can buy. But the idea that the car could see the road when I couldn’t, that the sensors would take over when I activated the Pilot Assist mode, it frightened me. Even though the whole point of the feature is to help the driver avoid steering off the road or plowing into another car, I found myself too anxious to fully trust the semi- autonomous technology that was keeping me safe. But I’m an anxious person. Someone braver would realize that this next step towards a fully autonomous vehicle represents a complete technological revolution, one that would save countless lives in the years to come. Intellectually, I believe this, too. Hurtling down the interstate at 7. Volvo’s computer vision and seemingly robotic steering wheel broke my brain. Let’s back up and go over the details of Pilot Assist, the semi- autonomous function I tried out on several hundred miles of highway. Volvo has offered a version of Pilot Assist on its cars since 2. To engage feature, you just tap the cruise control button on the steering wheel and then scroll over to the Pilot Assist option. It shows up as a green steering wheel on the dash as well as the head- up display. To disengage it, you just tap the brakes. I first tested it in a Volvo XC9. Pong with an SUV, since the technology would stop you from going off the road by bouncing you back in the other direction. Which is neat, but not necessarily mind- boggling. In 2. 01. 6, Volvo announced the second generation of the technology, an upgrade that qualified it as a Level 2 form of autonomous driving, according to SAE International’s scale. This, I was told, was the business. The new, more advanced Pilot Assist II currently comes standard on the Volvo S9. V9. 0 and XC9. 0. That’s not bad for a station wagon that starts at $5. The model I drove was slight souped up and had a sticker price of $6. If you have an XC9. Pilot Assist, you can get the upgrade for free through a software update. How does it work? Computers and sensors, my friend. Behind the Volvo V9. The feature will also maintain a minimum distance between you and the car in front of you. The new Pilot Assist II works great on the highway, but it also performs surprisingly well on windy country roads. You cannot, however, take your hands off the wheel. If you do, the car will catch you and put the feature on standby until you grab the wheel again. Even if your hand is touching the wheel and not moving, the Volvo instructs you to apply steering or Pilot Assist will turn itself off. You’d think this would be annoying, but keeping my hand on the steering wheel actually made me feel safer and more alert—which is probably the point. The Pilot Assist II feature will only work under 8. Pilot Assist I, which only worked at speeds up to 3. It’s all fun and games until you realize that you’re not paying attention to your driving—or at least not paying attention like you used to. I found myself scrolling through playlists on Spotify through the built- in Apple Car. Play. I stared off into the distance longer than I ever would’ve if I didn’t trust that the car wouldn’t let me crash. And when I caught myself drifting, my instinctual reaction was to overcorrect, and slam myself into the center of the lane. This is what’s always worried me about the transition to autonomous driving. For at least a few years, humans either won’t trust the cars to get them safely to their destination or they’ll trust the cars too much, believing that the semi- autonomous technology can do more than it can. This will be a real worry at least until we see an SAE Level 4 full, self- driving automation that will let a car completely control the trip. As former Gizmodo writer Alissa Walker argued last year, though, the humans in the car will still be at risk as long as they have the capability to override autonomous driving system, especially if they’re drunk. You wouldn’t imagine that in the back of a taxi, we put an extra steering wheel or brake pedal there for the passenger to grab ahold of anytime,” Google’s Chris Urmson told NPR at the time. It would just be crazy to think about doing that.”Accordingly, when Google designed Firefly, its vehicle for self- driving car testing, the company decided not to include a steering wheel or pedals in the design. Truthfully, the Firefly fleet didn’t need a steering wheel or pedals because it was being tested as a Level 4 self- driving car. Waymo, the company that spun off from Google’s self- driving car division, retired all 5. Firefly prototypes, however, in favor of 6. Chrysler minivans that are now conducting public testing in Phoenix. We don’t yet know if the company will eventually ditch the steering wheel and pedals on those vehicles. We do know that more autonomous cars will appear on roads all over the world in the few years. Waymo, the new Alphabet company that grew out of the self- driving car team at Google, has been testing its self- driving cars on public roads for years now. More recently, Uber has started testing its own autonomous vehicles, and Lyft plans to offer rides in self- driving cars by the end of this year. So in the near future, expect to see a lot more Level 2 cars like the Volvo V9. I would wager, expect to see more distracted drivers. If Volvo’s succeeded, however, that won’t lead to more road casualties, since its cars’ safety features are becoming so much more sophisticated. At the end of the day, it wasn’t Volvo’s technology that scared me. It was me. I could see myself developing bad habits and over trusting a technology that still has real limits. This is actually why Volvo and some other companies plan on skipping Level 3 models, which offer full, self- driving capabilities but require a driver to be present. Manufacturers are eyeing a straight jump to Level 4 functionality. That way people won’t be confused about which autonomous features any given car had and which ones it lacked. I know I was confused with the Volvo V9. I don’t like to feel confused while driving at high speeds. Then again, I’ll probably die before the self- driving takeover is complete. This technology isn’t for me. It’s for my kids and future generations of Americans. That is, if there’s even an America left by then. Bib. 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Following is a transcript of his presentation, edited for the sake of clarity. It is a pleasure to share with you record breaking results once again. Sales in local currency were actually up over 8% for the first six months. That reflects our ongoing guidance of growing strongly at a single digit. The Milwaukee growth engine was up again, over 2. Our power tool equipment segment demonstrated outstanding growth and momentum. In the first half it was up 1. I will share more detail with you in a moment about that. There are some fantastic highlights that made up that extraordinary level of growth. Floor care down 1. That number obfuscates a bit the momentum and the progress we are making in floor care. First of all we exited our shredder business which we were in last year. That was a significant business that we dropped completely. Secondly, the floor care cordless stick- vac market, stick- vac business for TTI in a number of different brands was actually up over 5. So our cordless floorcare focus area is growing like crazy. Of course the corded, the traditional legacy business, which was a big part of our floor care business in the past, is down sharply, and will continue to decline. The good news is that our cordless growth will overwhelm that. We have a bright future in our floor care business as you will see in the coming years. We were very excited about our first- half performance in gross margin. We were up another 5. Really it is a record- breaking trend. Our EBIT is up 1. That is after currency. This shows outstanding leverage. We actually maintained SG& A at a flat level, although we are investing like crazy in research and development on new products, which you will see in a moment, we still were able to generate excellent leverage. EBIT growth up over 1. Gross margin as we pointed out was up 5. This is encouraging. But when you look back for a moment on what we have been sharing with you for the past nine years, we have actually increased our gross margin as a percentage of sales over nine consecutive years from the 3. This is a track record that we are proud of. I can assure you that this trend will continue over the next five years. We have so much high- margin, accretive new product on the way that we believe we can continue to drive gross margin to higher and higher levels, which will generate increased EBIT percentages as we go forward. One of the basic productivity measurements we always use, is sales growth versus headcount, once again we grew sales 8% in change, while headcount grew by 2. So, with all the investments we are making in geographic expansion, around the globe, with all the money, and all the heads we are pouring into research and development, and product management, to generate this kind of productivity and leverage in headcount is encouraging. I am very pleased with our team's disciplined performance in controlling these expenses. We were able to grow our power equipment business in all regions. Actually, when North America has the slowest level of growth, you know that our geographic expansion efforts are gaining great traction. I was really excited about how our European team performed in the first half. And, of course, rest of world means Australia, New Zealand and South Korea, and those numbers are exciting as well. And then, when you shift gears and look at only Milwaukee, Milwaukee was once again up over 2. That 2. 0% is an exciting number on a small base, but when you have a significant base, which we now do in Milwaukee, 2. And yet we are committed to a 2. Milwaukee this year, the next five years. I don't think we have even scratched the surface yet in terms of the long- term potential of this vast cordless, industrial market that we are developing with our technology and our new products. You know, the geographic performance of Milwaukee is also a highlight. Again, North America up almost 2. I was really proud of our European team. The European theatre is a tough environment. And yet throughout Western Europe, actually Eastern Europe, including Poland and Hungary, Czech Republic, Slovenia, Bulgaria, Romania, etc., these Eastern European countries are really selling Milwaukee like crazy. And of course once again, rest of world means Australia New Zealand and South Korea, where we are growing at rates that are unprecedented. It is very exciting where this is all going to lead. Now in the first half, our largest competitor actually reported impressive results, in fact our largest competitor announced that their organic growth for the last six months of 2. And we were impressed with that. That shows good performance. Certainly our competitor trumpeted that as an outstanding performance. Except that, we were up 1. Of course, Milwaukee is up 2. Milwaukee out, our DIY brand was up 1. That is organic growth. Even the tactical AEG brand was up almost 1. So, while our competitor is doing well, you can see that there is nobody taking any market share from TTI. And I can tell you that there will be nothing but a continuation of this kind of trend, over the next five years with the new product flow that we have on the way. There is one other interesting thing. You know, a lot of investors have asked me about a new, flexible voltage launched by our largest competitor. I have been answering these questions for nine months. And it is interesting, that since our competitor launched this flexible voltage cordless system, our growth rate in Milwaukee cordless and Ryobi cordless have increased. So, while our competitor are doing great with their program, I'm sure, we are doing even better than we were before they launched. So, I think it is obvious that there is going to be no slowdown in Milwaukee, or Ryobi cordless growth, based on competitive actions. This is an example of our strategy at TTI. We don't worry about what our competition is doing. We don't worry about macro economic issues beyond our control. Or political issues that are brewing in various parts the world. What we worry about, is things that we can control. New product development, hiring outstanding people, motivating our team, having a disciplined strategy that we focus on relentlessly. We have a geographic expansion program, that is not based on headlines, on geographic regions, but very specific countries, specific attacks in markets, where, like in South Korea, or like in Australia, we have focused and attacked with our strategy and we have achieved great results. So, our competitors are doing a fine job, and we respect them. But we don't react to them, and I can assure you that we intend at TTI to, of course outperform our competitors for many, many years to come. Ryobi. Let me show you why I feel so confident. First of all the Ryobi brand, the Ryobi brand has become the most common brand in the world for DIY tools. This is an amazing statement. You know there was a brand called Black & Decker, it is a company I worked at for 1. It was number one in the world, for 8. For Ryobi to overtake the former leader, and to become the number one DIY brand in the world, is pretty special. The interesting thing is that not only are we number one, but we are outgrowing any other DIY brand in the world, and it is because of this amazing flow of cordless products. It is really the same strategy at Milwaukee and Ryobi. Ryobi One+ is now the number one brand of cordless tools in the world, and although we have over 1. One+ tools already, we are about to launch more in the next six months than at any former period in our company's history. So we have a new mitre saw, for Ryobi One+, that is the first ever cordless DIY mitre saw that performs like a corded tool. We have a new brushless motor cordless angle grinder, same technology as we use with Milwaukee. We were able to adapt it at the right price point for our Ryobi family, and with brushless of course you get more power, less weight. This thing will actually outperform a corded version of the same tool. Same with the brushless motor cordless Ryobi circular saw, this is a cordless circular saw that is lighter than corded, and will actually cut faster and more accurately than the corded DIY saws with which we compete. Then we have the metal shears, brand- new category, and then we have the pin nailer, brand- new category, then we have our second drain cleaning product. List of Chromium Command Line Switches. There are lots of command lines which can be used with the Google Chrome browser. Some change behavior of features, others are. · Security. Let's face it. Software has holes. And hackers love to exploit them. New vulnerabilities appear almost daily. If you have software - we all do - you need to. There’s more to a travel photographer’s kit than a camera body and a few lenses. Here are the essentials the pros always keep close at hand. ![]() ![]() The Essential Tools Inside a Pro Travel Photographer's Bag. There’s more to a travel photographer’s kit than a camera body and a few lenses. Here are the essentials the pros always keep close at hand. I shoved my phone in my husband’s face to show him a picture I’d taken of the New York skyline.…Read more I recently took a trip to Cuba with some professional photographers, filmmakers, and travel influencers to learn the ins and outs of capturing the world on (digital) film (full disclosure: this trip was paid for by Adobe). While we toured the colorful streets of Havana and navigated the luscious countryside of Viñales, I asked the pros to show me the inside of their bags in between shooting sessions. Renan Ozturk (@renan_ozturk), a photographer and filmmaker for National Geographic, Elisabeth Brentano (@elisabethontheroad), a professional landscape photographer, and a few other experienced travelers were gracious enough to show me everything they carried with them. Here’s a quick rundown: Air blower (mini- blimp or mini- rocket): A brilliant little device you squeeze to shoot out blasts of air. Perfect for cleaning dust and debris off your camera lenses and sensitive electronics. You can get one of Giotto’s blasters for about $1. Microfiber lens wipes: Microfiber cloths work well enough, but they absorb oils, dirty water, and pick up all that dust you’re cleaning off your gear. Disposable microfiber wipes like Kimwipes (box of 2. Plus, you can tear off a couple for your bag and put some in your pocket. Etip gloves: If you’re shooting somewhere cold and you’re shooting on your phone, or have any other touchscreen devices, these are a must. They also provide pretty good finger articulation, which is nice while you’re shooting photos. You can grab a nice pair from The North Face for around $3. Pocket hand warmers: These keep your hands warm, yes, but you can also use them to keep your extra camera batteries warm so they don’t die before you can use them. Also works well for keeping your phone from dying when it’s freezing out. The popular Hot Hands kind cost about $7 for 1. Flip- flops: Sometimes your excursions go from dry land to water, and it’s a good idea to keep your socks and shoes dry. Thin, easy to pack, and super cheap to boot (most pairs are less than $1. Sunglasses: Ozturk says sunglasses are like neutral density filters for your eyes. You invest in good glass for your camera, so why wouldn’t do the same for your eyes? You kind of need them for photography after all. Lightweight tripod: Ozturk’s preferred tripod is a carbon fiber model, while Brentano’s was an aluminum alloy model. Both super light, but these can be pretty expensive (like upwards of $2. This ZOMEI Aluminum Portable Tripod ($7. Socks: Always wear some nice socks, preferably synthetic or wool. In fact, Ozturk wears ski socks. They don’t get stinky as fast as cotton socks, and they last forever. You can buy a pair of Wigwam performance ski socks for less than $2. Rain gear: A lightweight rain poncho or rain jacket ($1. Not a bad idea to pick up a camera rain cover too ($1. Filters: Neutral density filters for shooting waterfalls beaches and other waterscapes, and a polarizing filter for shooting brightly lit skies and lakes. Nice camera strap: I was shown this nifty camera strap from Peak Design ($6. I bought one as soon as I got back in the states. Super sturdy, but cameras can clip on and off the strap in a snap. Mini photo printer: The Fujifilm Instax Smartphone printer ($1. Josh Haftel, the Adobe Photoshop Lightroom mobile product manager, showed me it has an excellent hidden use for travel photogs. You can give recently- shot photos to people in exchange for taking their photo instead of money tips. It’s especially great for kids when you want to give out gifts. Tablet and SD card dongle: Ozturk likes to edit his photos on the go (bus, train, plane, hotel lobbies, at dinner), using Lightroom Mobile on an i. Pad Pro. i. Pads are lighter than laptops, have just as much power (or at least as much as you need for photo edits), are super thin, have more screen real estate than a smartphone, and you can import RAW images for editing with an SD card dongle. I was so impressed with his workflow, I bought a used i. Pad Pro and adopted the same setup. Of course, there are a lot of other essentials you’d expect as well. Things like extra camera batteries, extra memory cards (stored in a plastic bag, not a carrying case), snacks (jerky, energy bars, etc.), lotion, sunscreen, chapstick, a hat that provides adequate shade, a portable charger (a solar- powered one if you’ll be in a sunny place), and maybe an extra camera body as a backup if you’re traveling to a place where camera repair won’t be possible. Whatever you pack in your own travel photography bags, Ozturk and Brentano both suggest you keep it as light as possible. See the best sites around the world often means a ton of walking, hiking, backpacking, and possibly even climbing. They stick to mid- range camera bags, which, when full, weigh around 2. But if they need to go super lightweight, they get their bags down to 5 to 1. In general, Ozturk recommends you ditch the original packaging and bulky cases—like memory card or battery cases—whenever you can. Pare down, carry less, and carry thin. As a solo traveler, it’s challenging to capture my adventures: I want to include myself in the…Read more. Two- Face - Wikipedia. Two- Face (Harvey Dent) is a fictionalsupervillain appearing in American comic books published by DC Comics, commonly as an adversary of the superhero. Batman. The character was created by Bill Finger and Bob Kane and first appeared in Detective Comics #6. Aug. 1. 94. 2).[3] As one of Batman's most enduring enemies, Two- Face belongs to the collective of adversaries that make up Batman's rogues gallery. Once an upstanding Gotham City. District Attorney, Harvey Dent was hideously scarred on the left side of his face after a mob bossthrew acidic chemicals at him during a court trial. He was subsequently driven insane and adopted the "Two- Face" persona, becoming a criminal obsessed with the number two and duality. In later years, writers have portrayed Two- Face's obsession with chance and fate as the result of schizophrenia, bipolar disorder, and dissociative identity disorder. He obsessively makes all important decisions by flipping his former lucky charm, a two- headed coin which was damaged on one side by the acid as well. The modern version is established as having once been a personal friend and ally of James Gordon and Batman.[4]The character has been featured in various media adaptations, such as feature films, television series and video games. ![]() ![]() For example, Two- Face has been voiced by Richard Moll in DC animated universe, Troy Baker in the Batman: Arkham series, Billy Dee Williams in The Lego Batman Movie, and William Shatner in Batman vs. Two- Face. His live- action portrayals include Billy Dee Williams and Tommy Lee Jones in the Batman film series, Aaron Eckhart in The Dark Knight, and Nicholas D'Agosto in the television series Gotham. In 2. 00. 9, Two- Face was ranked #1. IGN's list of the Top 1. Comic Book Villains of All Time.[5]Publication history[edit]Two- Face first appears in Detective Comics #6. Harvey "Apollo" Kent; [3] later stories changed his name to "Harvey Dent" to avoid an association with Superman (Clark Kent).[6]The character only made three appearances in the 1. By this time, he was dropped in favor of more "kid friendly" villains, though he did appear in a 1. Half Life 2 Episode 1 Crack Tpb TorrentsWorld's Finest Comics #1. Batman declared him to be the criminal he most fears. In 1. 97. 1, writer Dennis O'Neil brought Two- Face back, and it was then that he became one of Batman's arch- enemies. In his autobiography, Batman creator Bob Kane claims to have been inspired by Robert Louis Stevenson's Strange Case of Dr Jekyll and Mr Hyde, specifically the 1. Some inspiration was also derived from the Pulp magazine character the Black Bat whose origin story included having acid splashed on his face.[7]In the wake of Frank Miller's 1. Batman's origin (see Batman: Year One), Andrew Helfer rewrote Two- Face's history to match.[8] This origin, presented in Batman Annual (vol. Dent's status as a tragic character, with a back story that included an abusive, alcoholic father, and early struggles with bipolar disorder and paranoia. It was also established, in Batman: Year One, that pre- accident Harvey Dent was one of Batman's earliest allies. He had clear ties to both Batman and Commissioner Gordon, making him an unsettling and personal foe for both men.[9]Fictional character biography[edit]Harvey Dent's origin relates that he went through much hardship during his childhood. Growing up under the parentage of an abusive and mentally- ill father, Harvey Dent started developing repressed mental illnesses of his own, such as bipolar disorder and schizophrenia. His hard work ethic, however, later allowed him to rise as the youngest district attorney to serve Gotham City, nicknamed "Apollo" for his good looks and clean- cut image, at age 2. He is elected about six months before Batman takes his role as a masked vigilante.[8]Dent forges an alliance with police captain James Gordon and Batman to rid Gotham of crime boss Sal Maroni,[1. Carmine Falcone, with the former murdered by the latter's son. The following is a list of media relating to the anime and manga series Trigun by Yasuhiro Nightow. Manga Trigun Original release. Published in three volumes by. Two-Face in Batman and Robin vol. 2, #23.1 (2013). Art by Guillem March. Beskid Mały to niewielkie, lecz piękne pasmo górskie stanowiące część Beskidów Zachodnich. Portal ten został stworzony, aby Państwu przybliżyć ten cudowny. Gordon also speculated that Dent might have been Batman, but dismissed this theory on grounds that Dent lacked Batman's financial resources. Falcone hires the corrupt Assistant District Attorney Vernon Fields to provide Sal Maroni with sulfuric acid to disfigure Dent with. Two- Face gets his trademark coin from his father that would employ the coin in a perverse nightly "game" that always ended with a beating. This would instill in Dent his lifelong struggle with free will and his eventual inability to make choices on his own, relying on the coin to make all of his decisions. Eventually, the scarred Dent takes his revenge on Fields and Maroni, leading to his incarceration in Arkham Asylum.[1. Criminal career[edit]During the Batman: Dark Victory story arc, the serial killer. Hangman targets various cops who assisted in Harvey Dent's rise to the D. A.'s office. Two- Face gathers Gotham's criminals to assist in the destruction of the city's crime lords. After a climactic struggle in the Batcave, Two- Face is betrayed by the Joker, who shoots at Dent and thus causing him to fall into a chasm, presumably to his death. Batman admits in the aftermath that, even if Two- Face has survived, Harvey is gone forever.[1. ![]() During a much later period, Two- Face is revealed to have murdered the father of Jason Todd. When attempting to apprehend Two- Face, Jason briefly has the criminal at his mercy, but lets Two- Face's punishment be decided by the law.[1. Two- Face similarly serves as a 'baptism by fire' for Tim Drake. When Two- Face has Batman at his mercy, Tim dons the Robin suit to save Batman. In Arkham Asylum: A Serious House on Serious Earth, Arkham's doctors replace Dent's coin with a dice and eventually a tarot deck; but rather than becoming self- reliant, Dent is now unable to make even the smallest of decisions—such as going to the bathroom. Batman returns the coin, telling Two- Face to use it to decide whether to kill him. Batman leaves safely; but the implication made is that Two- Face chose to let Batman live.[1. In the No Man's Land storyline, in which Gotham is devastated by an earthquake, Two- Face claims a portion of the ruined city, takes up residence in Gotham City Hall, and forms a temporary alliance with Gordon to share certain territory. His empire is brought down by Bane (employed by Lex Luthor) who destroys Two- Face's gang during his destruction of the city's Hall of Records. Two- Face kidnaps Gordon and puts him on trial for his activities after Gotham City is declared a "No Man's Land", with Two- Face as both judge and prosecutor for Gordon's illegal alliance with him; but Gordon plays upon Two- Face's split psyche to demand Harvey Dent as his defense attorney. Dent cross- examines Two- Face and wins an acquittal for Gordon, determining that Two- Face has effectively blackmailed Gordon by implying that he had committed murders to aid the Commissioner.[1. In Gotham Central, Two- Face meets detective Renee Montoya. Montoya reaches the Dent persona in Two- Face, and is kind to him. He falls in love with her, though the romance is one- sided.[1. Eventually in the Gotham Central series, he outs her as a lesbian and frames her for murder, hoping that if he takes everything from her, she will be left with no choice but to be with him. She is furious, and the two fight for control of his gun until Batman intervenes, putting Two- Face back in Arkham.[1. In the Batman: Two- Face - Crime and Punishment one- shot book, Two- Face captures his own father, planning to humiliate and kill him on live television for the years of abuse he suffered. This story reveals that, despite his apparent hatred for his father, Dent still supports him, paying for an expensive home rather than allowing him to live in a slum. At the end of the book, the Dent and Two- Face personalities argue in thought, Two- Face calling Dent "spineless". Dent proves Two- Face wrong, choosing to jump off a building and commit suicide just to put a stop to his alter ego's crime spree. Two- Face is surprised when the coin flip comes up scarred, but abides by the decision and jumps. Batman catches him, but the shock of the fall seems to (at least temporarily) destroy the Two- Face side of his psyche.[1. In Two- Face Strikes Twice, Two- Face is at odds with his ex- wife Gilda Dent, as he believes their marriage failed because he was unable to give her children. She later marries Paul Janus (a reference to the Roman god of doors who had two faces). Sales. Force, Microsoft Dynamics and Sugar. CRM Professional. FULLY FEATUREDSupercharged Sugar. CRM, 1. 00s of enhancements completely open source. FIND OUT MOREFREE DOWNLOADSuite. CRM is open source and will always be free to Download. DOWNLOAD NOWSUPPORTProfessional support whenever you need it or use our commmunity forum. GET SUPPORTSECURE HOSTINGBlazing fast secure hosting to keep your Suite. CRM performing at its best. BOSSIE 20 Awards. SuiteCRM has won the BOSSIE Award 20 for the world's best Open Source CRM. "SuiteCRM continues to innovate and extend.If you.FIND OUT MOREEXTENSIONSBrowse our Extensions directory and find a plug- in you need. VIEW EXTENSIONSPARTNERSFind a local partner to support your Suite. CRM project. FIND A PARTNER. ![]() A Comprehensive Guide to Project Management Software Solutions. The project management software industry is currently dominated by a number of key software big. This web site presents a list of open source project management software tools that can be used for software development projects. Project management tools are often. ![]() ![]() Transdermal Delivery of Scopolamine by Natural Submicron Injectors: In- Vivo Study in Pig. Abstract. Transdermal drug delivery has made a notable contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. While transdermal delivery systems would appear to provide an attractive solution for local and systemic drug delivery, only a limited number of drugs can be delivered through the outer layer of the skin. The most difficult to deliver in this way are hydrophilic drugs. The aquatic phylum Cnidaria, which includes sea anemones, corals, jellyfish and hydra, is one of the most ancient multicellular phyla that possess stinging cells containing organelles (cnidocysts), comprising a sophisticated injection system. The apparatus is folded within collagenous microcapsules and upon activation injects a thin tubule that immediately penetrates the prey and delivers its contents. Here we show that this natural microscopic injection system can be adapted for systemic transdermal drug delivery once it is isolated from the cells and uploaded with the drug. Using a topically applied gel containing isolated natural sea anemone injectors and the muscarinic receptor antagonist scopolamine, we found that the formulated injectors could penetrate porcine skin and immediately deliver this hydrophilic drug. An in- vivo study in pigs demonstrated, for the first time, rapid systemic delivery of scopolamine, with Tmax of 3. Cmax 5 times higher than in controls treated topically with a scopolamine- containing gel without cnidocysts. The ability of the formulated natural injection system to penetrate a barrier as thick as the skin and systemically deliver an exogenous compound presents an intriguing and attractive alternative for hydrophilic transdermal drug delivery. Citation: Shaoul E, Ayalon A, Tal Y, Lotan T (2. Transdermal Delivery of Scopolamine by Natural Submicron Injectors: In- Vivo Study in Pig. PLo. S ONE 7(2). e. Editor: Wei- Chun Chin, University of California, Merced, United States of America. Received: October 2. Accepted: January 2. Published: February 2. Copyright: © 2. 01. Shaoul et al. This is an open- access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: These authors have no support or funding to report. Competing interests: T. Lotan is a co- founder of Nano. Hyoscine ScopolamineCyte (Israel) Ltd., and A. Ayalon and Y. Tal are company employees. Scopolamine Patch Withdrawal Syndrome. the rebound effects are.4 The pharmacological half-life of scopolamine in the body is about 9 hours, but. · The effect of transdermal scopolamine for the prevention of postoperative nausea and. and a short plasma half-life. Transdermal Scopolamine. The results of this study have been submitted by the authors, under the guidance of the company, to the European Patent Agency for IP protection. The authors declare that this does not alter their adherence to all PLo. S ONE policies on sharing data and material. Introduction. Transdermal delivery has advantages over conventional drug delivery systems in that it reduces first- pass metabolism, eliminates drastic drug fluctuations, prevents adverse side effects, and increases patient compliance. Onset Of Scopolamine PatchA variety of vehicles and technologies have been developed to penetrate the skin barrier [1], allowing transcutaneous drug delivery [2], [3]. The two main approaches employed to augment skin permeability and penetration are based on utilization of passive chemical enhancers or advanced active physical energetic devices. The passive approach includes the use of different types of topical formulations, including chemical enhancers, liposomes, ethosomes, or large reservoir- type patches [4], [5]. However, while these technologies have the advantage of high patient compliance, they usually require a prolonged application time and are limited to molecules that are both lipophilic and small. The physical approach primarily employs high- energy devices such as needle- free injectors, low- frequency ultrasound, iontophoresis, electroporation, microneedles, or thermal procedures [6], [7]. These advanced methods have the advantage of rapidly permeating the skin barrier, but they generally entail sophisticated devices, professional administration, higher costs, and lower patient compliance. ![]() · Scopolamine - Wikipedia, the free encyclopedia. use of a transdermal patch.[4] Scopolamine. data Bioavailability Half-life CAS number ATC code. Owing to these limitations relatively few drugs can currently be introduced transdermally, with particular difficulty experienced in the delivery of hydrophilic drugs through this route [8]. The phylum Cnidaria, dated to around 7. Activation of the microcapsule engenders a high internal pressure of 1. About 3. 0 subtypes of cnidocysts are known. They differ in size and shape, but all function according to the same basic principle (Fig. Discharge of the system is controlled by osmotic balance. Once the system is activated, water flows through the porous cnidocyst wall causing dissociation of a large aggregated matrix of poly- γ- glutamate trapped by cationic metal. This in turn increases the osmotic pressure, resulting in ejection of the tubule [1. The poly- γ- glutamate matrix serves as the internal “battery” of the system and this, together with the high tensile strength of the cnidocyst wall [1. We have previously shown that the sea anemone micro- injection system can be applied for topical delivery, is compatible with hydrophilic compounds, and is clinically safe [1. Figure 1. Mode of action of the cnidocyst system. The intact dry cnidocyst (a) is activated by the hydrophilic drug solution (b) water molecules (blue triangle) and the soluble drug (green circles) penetrate the porous wall of the cnidocyst, resulting in discharge of the tubule and injection of its microcapsule content through the tubule to the skin (c). The aim of the present study was to evaluate the potential use of the cnidocyst system as an active vehicle for systemic drug delivery. The drug of choice was scopolamine, as its delivery profile in topical applications is well documented. The animal model we chose was the pig, as it is similar to humans in its anatomy, genetics, physiology and biochemistry, and is well recognized as an experimental animal in biomedical research [1. It is a particularly reliable model for transdermal research in vivo because its skin is highly similar to human skin in having low hairiness, a thick strateum corneum, and similar dermis composition, as comprehensively reviewed by Simon and Maibach [2. Using a porcine model, we compared the pharmacokinetic profile of scopolamine following a single topical application of the cnidocyst system to that of a control topical application without cnidocysts. Materials and Methods. Ethics Statement. All animals in the study were handled according to the guidelines for efficacy testing of veterinary medical products (Rules Governing Medicinal Products in the European Union, Volume 7). The experiment protocol was approved by the Animal Care Committee of the Experimental Institute of the Veterinary Faculty of the Szent István University, Hungary. The ID number was PCG- 2. Chemicals and Formulations. Scopolamine hydrobromide solution (scopolamine HBr) and all reagents were purchased from Sigma- Aldrich (Israel) unless stated otherwise, and were of at least analytical grade. Acetonitrile (HPLC grade) and ethanol were purchased from Riedel de Haen (Seelze, Germany). Klucel® HF Pharm hydroxypropylcellulose (HPC) was received from Hercules Aqualon (Wilmington, DE, USA). The control gel formulation contained 2% HPC in absolute ethanol. The cnidocyst gel contained 0. Preparation of microcapsules. The sea anemone Aiptasia diaphana, when triggered mechanically, secretes thin filaments (acontia) enriched with microcapsules (Fig. We exploited this natural behavior to obtain filaments without harming the anemone. Microcapsules were isolated from the filamentous tissue as described previously [1. Briefly, filaments were incubated in 1 M sodium citrate, followed by two centrifugations in 7. Percoll gradients. The isolated microcapsules were washed with decreasing concentrations of Na. Cl (1 M to 0. 2 M) and freeze- dried. ![]() ![]() Apni pheli website (blog) kaise banaye google par or bo bhi bilkul free ek minute me. Gmail account ki madad se. Blogger google ki free subhida hai. Urdu Video Tutorials – Computer Ustaad The Largest Hub of Urdu Video Tutorials. A review of Manu Smriti's views on Shudras and Caste System. And why birth-based discrimination is totally against Manu Smriti. Educator Merit list District Kasur Tentative Merit Lists ESE Arts (Female)igetcontent. |
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